Bmp Studio 4 91 Rarity
314-BP FormulationLyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.ReconstitutionReconstitute at 50-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.ShippingThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.Stability & Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Cartier love ring serial number. 12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -70 °C under sterile conditions after reconstitution. 314-BP/CF FormulationLyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.ReconstitutionReconstitute at 50-200 μg/mL in sterile 4 mM HCl.ShippingThe product is shipped at ambient temperature.
Upon receipt, store it immediately at the temperature recommended below.Stability & Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.
Bmp Studio 4 91 Rarity Girl
3 months, -70 °C under sterile conditions after reconstitution. Background: BMP-4BMP-4 is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair (1-5).
The human BMP-4 precursor contains a 273 amino acid (aa) propeptide and a 116 aa mature protein (6). Processing of the propeptide by furin or proprotein convertase 6 enables the formation of the mature disulfide-linked homodimeric BMP-4 and facilitates its secretion. Similar intracellular processes may lead to the formation and recreation of BMP4/BMP7disulfide-linked heterodimer (7-9).
Mature human and mouse BMP-4 share 98% aa sequence identity. Human BMP-4 shares 85% aa sequence identity with human BMP-2 and less than 50% with other human BMPs. Compared to BMP-4 homodimers, BMP-4/BMP-7 heterodimers exhibit a greater potency in inducing osteogenic differentiation (9).
In Xenopus, the heterodimers can also induce the formation of mesoderm, whereas BMP-4 homodimers only provide ventralizing signals for existing mesoderm (10). BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12).
The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans (13-15). (2008) Blood 111:1933. Gambaro, K. (2006) Cell Death Differ. 13:1075.
Simic, P. Vukicevic (2005) Cytokine Growth Factor Rev. 16:299. Sadlon, T.J. (2004) Stem Cells 22:457. Frank, D.B.
97:496. Wozney, J. (1988) Science 242:1528. Cui, Y. (1998) EMBO J.
17:4735. Cui, Y. (2001) Genes Dev. 15:2797.
Bmp Studio 4 91 Rarity Pictures
Aono, A. (1995) Biochem. 210:670. Nishimatsu, S. Thomsen (1998) Mech. 74:75. Chen, D.
(2004) Growth Factors 22:233. Lavery, K. April 24 epub. Rosen, V. 1068:19.
Bmp Studio 4 91 Rarity Base
Jones, C.M. Smith (1998) Dev. 194:12. Takada, T.